Sperm DNA damage diagnostics: when and why

Sperm DNA damage diagnostics: when and why

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Sperm DNA damage is the major cause of defective sperm function. DNA damage includes DNA denaturation and sperm DNA fragmentation (SDF) and maybe the common underlying aetiology of infertility, recurrent spontaneous abortion (RSA) preand post-implantation losses, accelerated aging, and childhood cancer (1). Oxidative ...

Sperm DNA fragmentation testing: when and why?

tau.amegroups.com © Translational Andrology and Urology. All rights reserved. Guideline is information intended to advise people on how something should be done or what something should be, according to Cambridge Dictionary (1). In a medical context, “guidelines are a series of suggestions, issued by official bodies or by independent experts, for the conduct of medical practice. They include ad...

Measure of sperm DNA fragmentation (SDF): how, why and when?

Sperm DNA damage and its relation with leukocyte DNA damage.

DNA fragmentation in human sperm has been related to endogenous and exogenous factors. Exogenous factors can also affect leukocyte DNA integrity. This study evaluated the relation between sperm DNA damage and leukocyte DNA integrity, as a predictor of exogenous factors. DNA damage in the sperm and leukocytes of 41 individuals undergoing ICSI were measured by Comet assay. In addition, sperm chro...

Damage Control Orthopedics – When And Why

Care of a trauma patient with multiple injuries can pose complex problems of prioritization. For orthopedic injuries, we prefer to perform defi nitive fi xation of all fractures in one trip to the operating room. This approach not only makes the most effi cient use of the operating room and the orthopedic surgeon, but it permits the other injuries to be treated promptly, and allows the patient ...